Resumen

SUN, Yanling; LI, Li; XU, Wenxin  y  MA, Cen. Correlation between human papillomavirus infection and vaginal microecological environment, and the effect of Lactobacillus vaginal capsules combined with recombinant human interferon α-2b gel on human papillomavirus infection. Invest. clín [online]. 2025, vol.66, n.2, pp.131-146.  Epub 25-Jun-2025. ISSN 0535-5133.  https://doi.org/10.54817/ic.v66n2a01.

This study mainly analyzed the correlation between human papillomavirus infection (HPV) and vaginal microecological environment and explored the effect of Lactobacillus vaginal capsule combined with recombinant human interferon α-2b gel on HPV infection. Five hundred patients who underwent a gynecological examination in our hospital from June 2021 to June 2023 were selected and divided into HPV-positive and HPV-negative groups. Relative to the HPV-negative group, the HPV-positive group presented a higher abnormal rate of Lactobacillus, catalase, cleanliness, neuraminidase and proline aminopeptidase (p<0.05) and a higher positive rate of bacterial vaginosis (BV) (p<0.05). Multivariate logistic regression analysis showed that catalase, proline aminopeptidase and BV were risk factors for HPV infection (p<0.05). In addition, 180 HPV-positive patients were randomly divided into a control group (CG) and an observation group (OG). The CG was given recombinant human interferon α-2b gel, and the OG was treated with recombinant human interferon α-2b gel plus a Lactobacillus vaginal capsule. Relative to the CG, the OG presented a higher total effective rate (p<0.05), lower inflammation (p<0.01), better immune function (p<0.01), and a higher proportion of grade II-III vaginal flora density and grade II-III vaginal flora diversity (p<0.001). Collectively, HPV is significantly correlated with the vaginal microecological environment, and catalase, proline aminopeptidase and BV were closely related to HPV infection. In addition, Lactobacillus vaginal capsule plus recombinant human interferon α-2b gel has practical clinical efficacy, which can reduce inflammation, promote immune function, improve vaginal microecological environment, and is safe in the treatment of patients with HPV infection.

Palabras clave : human papillomavirus infection; vaginal microecology; bacterial vaginosis; Lactobacillus vaginal capsule; recombinant human interferon α-2b gel.

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