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Investigación Clínica
versión impresa ISSN 0535-5133versión On-line ISSN 2477-9393
Resumen
BRICENO-PEREZ, Carlos; BRICENO-SANABRIA, Liliana; REYNA-VILLASMIL, Eduardo y VIGIL-DE GRACIA, Paulino. Long-term effects of antenatal administration of corticosteroids. Where are we?. Invest. clín [online]. 2025, vol.66, n.3, pp.332-346. Epub 08-Sep-2025. ISSN 0535-5133. https://doi.org/10.54817/ic.v66n3a09.
There is increasing concern about the long-term effects of antenatal administration of corticosteroids, as some complications have been reported in neonates, adolescents and adults, which could be transmitted to subsequent generations, as it has been shown in animal and observational studies in humans. In this review, we summarize the current understanding of the long-term effects of antenatal corticosteroid administration and provide data to inform the preparation of guidelines. A literature search was performed in the PubMed database. A mechanism has been proposed as to how antenatal administration of corticosteroids could produce morbidity in neonatal neurodevelopment and lead to future diseases in adulthood. However, this hypothesis has not been proven in large randomized controlled trials. We summarize here the current data supporting and opposing the long-term effects of antenatal corticosteroid administration. Follow-up studies from randomized controlled trials have found no increased risk of neurologic impairment in children after exposure to a single course of antenatal corticosteroids. Observational and clinical trials of maternally administered antenatal corticosteroids show no evidence of increased disability on follow-up and describe associations rather than a proximate cause. Before 34 weeks of gestation, antenatal administration of corticosteroids in women at high risk for preterm birth appears to improve most neurodevelopmental outcomes. It is still recommended to administer a single course of corticosteroid treatment before preterm delivery.
Palabras clave : corticosteroids, pregnancy; betamethasone; dexamethasone; delayed effects of medical treatment; neurologic manifestations; premature birth.
