Resumo

ARAB, G et al. Función de los inhibidores de la Hidroxi-Metilglutaril Coenzima a Reductasa en la enfermedad Cardiovascular. AVFT [online]. 2003, vol.22, n.1, pp.13-18. ISSN 0798-0264.

ABSTRACT     We are including revision on atherosclerosis, the different types of tisular changes described in this pathology, the theories that could explain its physiopathology, the risk factors and its complications. The cholesterol metabolism and transport is described and the findings of several studies demonstrating cholesterol and triglyceride high serum levels as risk factors for atherosclerosis and coronary events. Description is made of the endothelial dysfunction and its relation with early cardiovascular events.     The action and use of statins (competitive inhibitors of the action of the hepatic enzyme hydroxymethyl glutaryl coenzyme A reductase -HMG CoA reductase-, stopping the conversion of HMGCoA to mevalonic acid, the principal precursor of endogenous cholesterol) in the prevention of cardiovascular events. How statins have actions in the production of nitric oxide, interaction white blood cell and the endothelium, antioxidant, antithrombotic and cytoprotective actions. There are also included other effects described for these drugs and the benefits when administered for the prevention of cardiovascular diseases.

Palavras-chave : Statins; Atherosclerosis; Endothelial function.