Resumen

CONTRERAS, KM et al. Evaluación comparativa de la eficacia y tolerabilidad del Cefadroxilo vs Oxacilina en el tratamiento de las infecciones de piel y tejidos blandos. AVFT [online]. 2003, vol.22, n.2, pp.111-115. ISSN 0798-0264.

ABSTRACT Objective: Compare the effectiveness and tolerability of the cefadroxil vs oxacillin in the treatment of the skin and soft tissue infections. Population and Methods: A randomized controlled study, in single blind fashion, of groups in parallel was carried out. A total of 98 patients were divided at random in two groups to receive cefadroxil (47 patients) or oxacillin (51 patients). A basal clinical examination was performed on zero time, that included local evaluation of the lesion with inflammation scale of 15 points, besides basal temperature and white cell count. We repeat this evaluation at 48 hours, at the 4th day and day 10. In the comparison of effectiveness we were considered the parameters of clinical cure, clinical improvement and therapeutic failure, the modification on inflammation scale, temperature and cell count were also analyzed. Results: The obtained data demonstrated that it was proven definitive cure in 95% of the cases with cefadroxil that was better to the group treated with oxacillin (86%). The therapeutic failure rate was 4% with cefadroxil and 18% with oxacillin. The results of the intragrupal comparison on day 0 vs day 2, and day 0 vs 4, demonstrated a significant reduction in the inflammation scales of the treated groups. Both treatments achieved a significant clinical improvement of the inflammatory scale on days 4 to 5, allowing the change from parenteral route to the oral, in that period. The definitive cure was achieved in mean of 8 days. There were not significant differences in the time of descent of the basal temperature. As for the white counts, it could be proven a remarkable descent and sustained in both groups of treatment, reaching statistical significance in days 2 and 4. Only two patients in each group were removed by adverse effects (cefadroxil 4% and oxacillin 5%). Conclusions: We concluded that the cefadroxil has a superior therapeutic effectiveness against oxacillin in the treatment of slight to moderate infections of skin and soft tissue, oxacillin showed a higher percentage of therapeutic failure and both were safe drugs in the treatment of this infections, showing a low proportion of adverse effects.

Palabras clave : Skin infections; Soft tissue; Cefadroxil; Oxacillin.