Abstract

OBREGON, O; LARES, M del C; CASTRO, J  and  GARZAZO, G. Potencial de oxidación de las Lipoproteínas de baja densidad en una población normal y en una población con diabetes mellitus tipo 2. AVFT [online]. 2004, vol.23, n.1, pp.25-29. ISSN 0798-0264.

The lipids peroxidation is a complex process, where unsaturated fatty acids react with molecular oxygen by a mechanism of chain reaction via free radicals, form hidroperoxides which are degraded to a variety of products like alkenals, hidroxialquenals, ketones, alkenos, and others, which can be quantified by different methodologies, like malondialdehyde (MDA), a final product of the degradation of fatty acids. In the present work we determined the susceptibility of low density lipoproteins to be oxidized, in two populations one normal (n=30) between 25-35 years and other with diabetes type 2 (n=25) between 25-50 years, without previous treatment of antioxidant. The extraction of the LDL by ultracentrifugation, oxidized in vitro, and then MDA was determined by the thiobarbituric acid method. The results of malondialdehyde in the normal population was between 0,77 to 1,17mmol/L and in the diabetics population from 1,47 to 2,11 mmol/L with stadistic difference between both population. In conclusion, the normal values of MDA are from 0,77 to 1,17mmol/L, greater values could be indicative of additional risk in these patients.

Keywords : Malondialdehyde (MDA); Diabetes mellitus type 2; LDL.