Resumen

TELLEZ-MENDEZ, R et al. Beneficios independientes de la reducción de la presión arterial en pacientes tratados con Nifedipina en microgránulos. AVFT [online]. 2004, vol.23, n.2, pp.118-121. ISSN 0798-0264.

Background: The dipper status is an independent risk factor in the hypertensive patients (Risers-R->Non dipper-ND->Dipper-D->Extreme dipper-ED-). We evaluated the effect of new nifedipine once day in micro-granules (NMG) on the nocturnal blood pressure fall, measurement by ABPM. Methods: Were included hypertensive patient (SBP ≥ 140 mmHg and/or DBP ≥ 90 mmHg, measurement with sphygmomanometer) that received 30 o 60 mg/day in a prospective, open and crossed in the time-doses 8 am or 8 pm study and that after the six week of treatment if SBP were < 140 mmHg with. Results: We recruited 73 patients, 40 (54.8%) maintained their status: ND n = 22 (night SBP fall between 0 and 10%), D n = 16 (night SBP fall between 10 and 20%) and R n = 2 (nocturnal increase in SBP). The other 33 patients (45.2%) change their status, five: 3 D and 2 ND change to ED (night SBP fall > 20%), eleven: 2 ED and 9 ND change to D, fourteen: 6 R, 1 ED and 7 D changed to ND, and three: 3 D change to R. There were no statistical difference with nocturnal blood pressure dipping change among the groups (30 or 60 mg), 17 patients improved their status (9 ND and 2 ED to D and 6 R to ND) and 16 patients D, maintained it. Conclusions: These results suggest that NMP offers in the 45% of the patients maintained or improve the status like as an independent benefit for the reduction of the blood pressure that could result in a better prediction of cardiovascular events and influence the prognosis for stroke.

Palabras clave : Nifedipine in micro-granules; Status dippers; Blood pressure.