Abstract

DIAZ, E  and  ISRAEL, A. Papel de la aldosterona y las glándulas suprarrenales en la acción renal de la adrenomedulina administrada centralmente. AVFT [online]. 2004, vol.23, n.2, pp.127-135. ISSN 0798-0264.

Adrenomedullin (AM) is a hypotensive peptide that is highly expressed in the central nervous system. Central AM increases water and salt intake, arginine-vasopressin secretion and produces diuresis and natriuresis. In adrenal glands AM inhibits aldosterone (ALD) secretion induced by angiotensin II, KCL or ACTH. We assessed the hypothesis that a diminished mineralocorticoid effect on the kidney may explain the natriuretic phenomenon. In control or sodium depleted rats, plasma ALD remained unchanged for up to 15 minutes after AM-IVT. Natriuresis induced by AM-IVT was not significantly affected in the absence (ADX rats) or excess of plasma ALD (SHAM+ALD), or in ADX rats, with or without hormonal treatment. Our results suggest that AM plays a role in the central regulation of water and electrolyte balance, and that AM natriuretic effect is unrelated to mineralocorticoids plasma levels or to the adrenal glands.

Keywords : Adrenomedullin; Aldosterone; Adrenalectomy; Natriuresis; Diuresis.