Resumen

HURTADO, MP  y  GVRB et al. Resistencia de staphylococcus aureus a los antimicrobianos en Venezuela 1988-1998. AVFT [online]. 2004, vol.23, n.2, pp.159-165. ISSN 0798-0264.

S. aureus is an important pathogen, both in hospitalized subjects and in the community. S. aureus’ antibiotic resistance was analyzed. We grouped the anti-microbial agents according to clinical use and pharmacological structure. We studied 30.344 isolates recuperated from hospital and community infections from 23 bacteriology laboratories registered in the data-base of the Surveillance Program of Bacterial Resistance to Antimicrobials in Venezuela (GVRB). Resistance being determined by the method of disc diffusion, following the NCCLS breakpoints. Results were as follows: first line antibiotics: oxacillin shows descent of 64% of variability according to the initial series value when applying the statistical tools for the Analysis of Chronological Series; vancomycin’s resistance descended 100%. Those descent are probably due to more careful procedures: ampicillin-sulbactam’s resistance raised 66,70%; aminoglycosides: amikacin lowered resistance in 50% and gentamicin in 63,20%; for the quinolones, cyprofloxacin raised values in 300% and norfloxacin in 50%. Among other antimicrobial tested, all of the group have reduced the resistance values. We consider that vancomycin should be reserved exclusively for patients with severe infections by S. aureus isolates where it has been demonstrated resistance to oxacillin.

Palabras clave : Staphylococcus aureus; Bacterial resistance surveillance; Antimicrobials.