Abstract

BERMUDEZ-PIRELA, V et al. Quimioprevención del cáncer de mama: fronteras y horizontes. AVFT [online]. 2005, vol.24, n.1, pp.32-41. ISSN 0798-0264.

Estrogenic action modulation to the mammary tissue has constituted the only therapeutic strategy in the chemoprevention of the breast cancer. Selective estrogen receptor modulators or SERMs are the most widely used drugs with this function, receiving great attention in this field. Nevertheless, the recent increase in the knowledge of molecular targets and intracellular routes related to the carcinogenic process have opened the possibility to the use of several active compounds with a chemopreventive function, these compounds comprise natural product found in normal diet named "phytochemicals", like carotenoid, phytoestrogens and certain vitamins. PPARs (peroxisome proliferator activated receptors) agonists have been postulated as possible anti-cancer drugs. Thus, drugs like thiazolidinediones constitute one of the recent and promising strategies in the field of the chemoprevention.

Keywords : Chemoprevention; Breast cancer; SERMs; Phytochemicals; PPARs.