Abstract

CALDERON DE C, L et al. Efectos de la N-Acetilcisteína y Metionina en intoxicación aguda con plomo en ratas wistar. AVFT [online]. 2006, vol.25, n.1, pp.33-38. ISSN 0798-0264.

Lead is a ubiquitous element in the environment. Oxidative stress is considered a mechanism which causes toxicity. The objective of this work is to determine the effect of N-Acetylcyteine and Methionine on lead poisoning in blood levels for lead, hematocrit, ALA-D and levels of malondialdehide (MDA) in the liver and kidneys. Sixty Wistar rats with an average weight of 185 g. were used. They were divided into five groups. In Group 1, the control, basal levels were determined, in Group 2, intoxication and in the rest of the groups, once intoxicated, they received treatment in the following manner: Group 3, N-Acetylcyteine (NAC). Group 4 Methionine (MET) and Group 5 NAC + MET. Results showed that NAC lowers lead levels in the blood in 23% (p<0.05) increases hematocrit and ALA-D activity. The combination of NAC + MET lowers the levels of lead in the blood in 41% (p<0.001) with a hematocrit increase (p<0.05) and an increase in the ALA-D activity of 16% (p<0.001). With respect to the MDA in the liver and kidneys, NAC lowers the levels of MDA in the liver in 29% (p<0.05). The NAC +MET treatment induces a statistically significant MDA increase in the liver and a decrease in the kidney. In this research, it can be concluded that NAC shows a weak Chelate effect on the plasmatic levels of lead and reverts alteration at the level of the blood parameters studied in addition to reverting lipidic peroxidation at the hepatic level. The combination of NAC + MET has dual behavior, at the hepatic level it is pro-oxidant and at the renal level antioxidant.

Keywords : lead poisoning; products reactive to thiobarbituric; N-Acetylcyteine (NAC); Methionine (MET).