Resumen

VASQUEZ DE RICCIARDI, Laura et al. Influence of gentamicine on the pharmacokinetic of a pentavalent antimonial compound Glucantime^® Influence of gentamicine on Glucantime kinetic. AVFT [online]. 2006, vol.25, n.2, pp.60-63. ISSN 0798-0264.

The pharmacokinetic parameters of Glucantime^® was studied after alone administration and in combination with gentamicine, to determine the effect of the aminoglucoside on the plasmatic concentrations and the pharmacokinetic parameters the metal. Four injected dogs were used with unique daily dose of alone Glucantime^® (25.65 mg kg^-1) and Glucantime^® + gentamicine (25.65 mg kg^-1 and 5 mg kg^-1, respectively). The blood samples were collected 0.25, 0.75, 1.0, 2.0, 4.0, 8.0, 12.0 and 24.0 hours post-treatment. Determination of antimony was carried out using atomic absorption spectrometer. The results demonstrated that the combination modifies the depuration of the metal and their sanguine decline resulted in plasmatic concentration minors. The pharmacokinetics parameters evaluated only Cl_B showed a statistically significant difference (0.353 ± 0.110 to 0.733 ± 0.33 mL h-1kg^-1) suggesting minor tisular persistence of antimony when administered together with gentamicine. It is important to recognize in future if the gentamicine interferes with the analysis of the antimony concentration o viceversa.

Palabras clave : Pharmacokinetic antimony; N-methylglucamine antimoniate; Glucantime; gentamicine.