Resumen

SANCHEZ, S et al. Efectividad y tolerabilidad de la citicolina (somazina®), en el tratamiento de pacientes con deterioro cognitivo tipo demencia (COD. S0012002). AVFT [online]. 2006, vol.25, n.2, pp.101-103. ISSN 0798-0264.

Summary Objectives: To evaluate the citicholina administered to dose of 1000 mg daily during 12 weeks in patient with dementia, MMST <24 points, with the purpose of observing the changes in MMST and in the quality of life. Methods: Was carried out a study, phase IV, prospective, open, multicentric, where was included patient of both sexes with ages between 45 and 85 years and deterioration of the mental function for: the old man’s mental deterioration, or chronic vascular dysfunctions, with a Score in M.M.S.T between 12 and 23. The Citicholina was given (CDP.cholina) in drops in dose of 1000mg. 10 cc (2 spoonfuls) daily during 3 months. The effectiveness was evaluated by means of the changes in the scores of: Minimental State Test, Scale of Quality of life of Barthel, the patient or caretaker’s opinion, and opinion of the doctor at the times: 0 days; 1,5 and 3 months of treatment. Results: Completed the study 55 patients. Most of the patients were taked another type of medications and these they keep without changes from the beginning until the end of the study. The patients presented a discreet descent in the in both positions and in the diastolic arterial pressures in the seated position between the beginning and the 6ta week without later modifications. We observed an important increment in the averages of the MMST, 92% of the patients improved the results, 32% the change was bigger than 5 points and 18% of the patients had normal results at the end of the study. 2 of 3 with severe dementia passed to moderate dementia (10 at 16 points and 10 to 15 points). 10 of 19 passed of moderate dementia to light and 9 patients passed from moderate dementia to a normal score. Tolerability: Seven patients presented adverse effects: sickness, restlessness, nauseas, diarrhea, insomnia, epigastralgia, worsening motor, anger, two patients suspended (sickness, attacks of anger) and two needed treatment (sickness: cimnarizina; anger: alprazolan).

Palabras clave : Cognitive deterioration; Citicholina; Dementia.