Resumen

TORRES, Marysabel et al. Efecto del diltiazem sobre los lipidos sericos y lesiones ateroscleroticas en conejos hipercolesterolemicos. AVFT [online]. 2007, vol.26, n.2, pp.120-126. ISSN 0798-0264.

Effects of diltiazem on seric lipids and atherosclerotics lesions in hypercholesterolemics rabbits. The purpose of this study was to evaluate whether the  administration of dilltiazem (30mg/day/oral route) decreases hypercholesterolemia and inhibits atherosclerosis in 38 male hypercholesterolemic rabbits. Control rabbits were given a standard diet for twelve weeks; Experimental rabbits were given: Group A: 0.3% cholesterol-enriched diet (HD) for twelve weeks. Group B:  HD for 12 weeks and diltiazem from week 3 until week 12. Group C: HD for  two weeks and  standard diet + diltiazem  from week 3 until week 12. Group D: HD for two weeks and standard diet from week 3 until week 12. Biochemical assays of Total Cholesterol (TC), LDL-cholesterol (LDLc) and Triglycerides (Tg) were done by enzymatic methods. The rabbits were sacrificed at week 12 and a histological study was carried out using the following methods: 1. Hematoxylin-eosin for determined the presence of lesions. 2. Gomori´s:  determined depth of lesions. 3. Computarized: determined extent of lesions. In groups A and B, TC, LDLc and Tg increased significantly in relation to control in all periods, with the exception of Tg at  week 12. Regarding atherosclerotic lesions, groups A and B presented Type II, III, IV and V; average percentages of lesion extent were : Group A: 47.20% and Group B: 57.60%. These results suggest that diltiazem exerts a hypolipidic effect when administered in conjunction with a 0.3% cholesterol-enriched diet. It was confirmed that an adequate diet is a sound preventive strategy against dyslipidemia, and that diltiazem does not prevent or induces regression of atherosclerotic lesions.

Palabras clave : diltiazem; hypercholesterolemia; rabbits.

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