Resumo

FERNANDEZ-PENA, Carlos; GONZALEZ-MUJICA, Freddy; MOTTA, Norma  e  TILLETT, Stephen. Efecto del extracto acuoso de hojas de Bauhinia megalandra sobre la glucogenólisis hepática en ratas. AVFT [online]. 2008, vol.27, n.2, pp.129-131. ISSN 0798-0264.

The Bauhinia megalandra leaves aqueous extract, has been commonly used in Venezuela for the empiric treatment of diabetes mellitus. In this work, the effect of B. megalandra aqueous extract on hepatic epinephrine or dibutyril cAMP stimulated glycogenolysis, was studied. The oral administration of the plant extract to feed rats decreased the epinephrineraised glycemia in a statystical significant way. Furthermore, liver slices from feed rats, incubated in the presence of B. megalandra extract, released less glucose in response to epinephrine or dibutiryl cAMP than controls. This results shows a decrease in the hepatic glycogenolysis due to the effect of B. megalandra leaves aqueous extract probably as result of the inhibition of the glucose-6-phosphatase enzyme.

Palavras-chave : Glycogenolysis; Bauhinia megalandra; epinephrine; glucose-6-phosphatase; dibutiryl cAMP.