Abstract

CHACON LOZSAN, Francisco J; BONFANTE-CABARCAS, Rafael Armando; DAZA, Damelis  and  GARCIA, Douglas. Efectos de la administración crónica de alcohol sobre la conducta motora y su relación con el sistema colinérgico muscarinico en ratas Sprague Dawley bajo estrés discontinuos. AVFT [online]. 2009, vol.28, n.2, pp.66-71. ISSN 0798-0264.

Alcohol consumption and stress are health problems, which affects the Cholinergic Muscarinic Receptor (CMR) system. Here we studied the effect of both phenomena on CMR functionality and densities. Methods: 43 Sprague Dawley rats were divided in 4 groups: Control (n=11), Stress (n=10), Alcohol (n=10) and Alcohol-Stress (n=9). Alcohol groups received 10% ethanol ad libitum in substitution of water every day, stress groups were submitted 3 days at week to 5 min force swimming at 5°C. Results: rats that had alcohol displayed addiction and hypermotility, the effect was higher at alcohol-stress group. Scopolamine significantly increased motility in all groups. No differences were observed at Rotarod performance. CMR density was decreased in hippocampus of rats belonging to alcohol group. Conclusion: alcohol induces motor disturbances related to CMR system.

Keywords : Alcohol; Stress; Muscarinic Receptor; Forced Swimming; Motility.