Resumen

NORIEGA ALVARADO, José Rugby et al. Modifications in the enzymatic liver markers promoted by the venom of joung cotralus DURISSUS CUMANENSIS. AVFT [online]. 2010, vol.29, n.4, pp.72-75. ISSN 0798-0264.

To determinate the effect of the venom of young Crotalus durissus cumanensis on levels of ALT, AST and AP, Balb/C mice were inoculated intraperitoneal with 0,75 mg/Kg of purified venom. Serum samples were obtained at different post-injection intervals (1, 3, 6, 12, 24h) and serum levels of ALT, AST and AP were determined. A significative difference (P ‹0,01) was observed in serum levels of ALT at 6h and at 24h post-venom injection, with a maximum of 587,64 U/L at 24 h, when compared with controls. In addition, AST shows a significative elevation between 1h and 12h post venom injection, with a maximum level of 2327 U/L at 3 h, while AP only showed significant differences at 24 h post-venom injection. These results suggest that the venom of young Crotalus durissus cumanensis induced liver-biliar injury, with a possible effect on skeletal muscle and/ or cardiac tissue.

Palabras clave : Crotalus; Liver injury; Alanin-amino transferase; Aspartate-amino transferase; Alkaline Phosphatase.