Abstract

VIRGA, Carolina; AGUZZI, Alejandra  and  DE LEONARDI, Adriana. Effect of Alendronate and Pamidronate administered subcutaneously in bone mineral density in experimental animals. AVFT [online]. 2012, vol.31, n.4, pp.84-87. ISSN 0798-0264.

Bisphosphonates are a class of drugs capable of modulating bone turnover and decrease their repairs when there is excessive reabsorbtion. The aim of this study was to investigate radiographic diagnostic of subcutaneous formulations based on Alendronate (AL) and Pamidronate (PA). Materials and methods: The pharmaceutical formulations were prepared with dosing for AL of 0.5 mg / kg weight, and BP of 0.6 mg / kg. They added special buffer with a pH of 5.5 in sterile media. The control (C) was saline. Results: Radiographic studies showed that AL from day 0 begins to increase mean bone mineral density (BMD), finding the peak at 30 days with a value of 157.9, beginning to decline until day 60 where the values stabilize, reaching at day 90 with a value of 156.1. PA behaves just the start of treatment but has its peak at 45 days with a value of 161.8, declining in the following days and stabilized after 90 days with a value of 156.2. The control remains in stable values over time from 15 days down from 152.4. (P <0.001). Conclusion: This study suggests that subcutaneous application of bisphosphonates may be effective as an add-on therapy to reduce bone reabsorbtion after oral surgery.

Keywords : Bisphosphonates; Bone reabsorbtion; Dental implant.