Resumen

ALVAREZ, Judith. Effect of extract of depigmenting French Marine Pine (Pycnogenol®) in patients with facial hyperchromia. AVFT [online]. 2014, vol.33, n.1, pp.1-6. ISSN 0798-0264.

Melasma is defined as the increase in skin pigmentation, particularly in the areas of the face exposed to sunlight such as the cheeks, forehead and chin. Methods: We conducted an open study to assess the effect of lightening the French Marine Pine extract (Pycnogenol®) in patients with melasma. Patients received standardized extract of French Marine Pine (Pycnogenol ®) 50 mg TID for 12 weeks. Patients were evaluated at weeks: 0, 4, 8 and 12. The changes were evaluated through, MASI index and measures of quality of life by Sp-MELASQUOL. Results: 50 patients were admitted to the study. Age 52.25±11.51 years, 87.5% were women. 77% were located in Patrick Fitz types III and IV. To start, MASI scale was 3.04 ± 2.04, at 8 weeks of 2.41 ± 2.09 (p = 0.00) and 12 weeks (2.09 ± 1.58, p = 0.000). MELASQUOL assessment revealed a statistically significant improvement in quality of life, going from 19.5 at baseline to 10.33 ± 0.65 at 8 week (p = .02). There were three adverse effects, only one discontinued treatment. Conclusions: The standardized extract of French Marine Pine, Pygnogenol®, was safe and effective in the treatment of Melasma.

Palabras clave : Melasma; standardized extract French Marine Pine; Pygnogenol.