Resumo

CANO, J et al. Nitric oxide as a marker of blunt trauma without intraabdominal damage. AVFT [online]. 2015, vol.34, n.1, pp.11-15. ISSN 0798-0264.

Introduction: Trauma has an important physiologic response in almost every single organ and system.. Nitric oxide sintasa induction do to Trauma and important bleeding could have a devastating consequence however during these conditions research has showed vasoconstriction and not vasodilatation. The reason of this inhibition is unknown. Our goal was to determine the Behavior of important mediators in the inflammatory response do to trauma; Nitric Oxide (NO), Malondialdehyde (MDA) and C Reactive Protein. Methods: This was a prospective observational study undertaken between Janurary 2009 and December 2009. 19 Patients with a mean age mean age of 25,3 ± 2,1 with blunt trauma without clinical evidence of intraabodminal injurie were managed at the Adult emergency trauma area of the University Hospital of Maracaibo-Venezuela. Blood samples were withdrown immediately to their admission. ON/MDA and C reactive protein were determine to later compare results with control healthy group. Results: NO was significally increased in trauma patient when compared with control group (24,7± 5,1 vs 20± 3,3 p:>0,02) No changes were observed in MDA and PCR in Trauma patients when compare with control group(1,5± 0,1 vs 1,3± 0,4p: >0,26). Conclutions: Our research showed that elevated NO with out an increase of MDA and CRP suggest blunt trauma without intraabdominal injurie. The need to have a larger study group that include intraabdominal injury do to blunt trauma is an important step to determine inflammatory behavior in trauma.

Palavras-chave : Closed Abdominal Trauma; Nitric Oxide (NO); Malondialdehyde (MDA).