Abstract

ARCAYA, José Luis et al. Effect of anti-inflammatory drugs, ibuprofen, acetaminophen and meloxicam and the survival of the Drosophila melanogaster. AVFT [online]. 2015, vol.34, n.3, pp.42-46. ISSN 0798-0264.

Dysregulation of inflammatory mechanisms are associated to aging and neurodegenerative diseases. Several authors have proposed that genes related to pro-inflammatory effects are involved in aging. In the present study, the effect of long-term treatment with Ibuprofen (IBU), Acethaminophen (ACET) and meloxicam (MEL) was evaluated in Drosophila melanogaster. At the concentrations tested these drugs induced in the mayority of the cases, a decrease of the lifespan in both sexes. These results suggest that adverse effects of these compounds predominate in this animal model.

Keywords : Drosophila melanogaster; aging; meloxicam; ibuprofen; acethaminophen.