Resumen

CHAHIN, Ramez Constantino. Drug Interactions in hospitalized patients in the Internal Medicine Hospital University " Dr. Angel Larralde ": June 2014 - December 2015. AVFT [online]. 2016, vol.35, n.1, pp.1-6. ISSN 0798-0264.

Introduction: Currently the proliferation of drugs complicates prescribing physician for proper and unerringly handled, gaining importance when the existence of the doctrine known as “Rational Prescription Drug” a discipline that leads inescapably to who makes farmacomedicación to be have this prudent and stay updated; drug interactions considering those changes on the pharmacokinetics , mechanism of action, or the effect of a drug can produce another drug, food or other substances when administered concomitantly. Objetive: Determine drug interactions in patients hospitalized in Internal Medicine, University Hospital “Dr. Angel Larralde”. Materials and methods: The medical records of patients hospitalized in Internal Medicine at University Hospital were reviewed “Dr. Angel Larralde” in the June 2014 period - December 2015, being constituted the sample for the first 104 medical records that met the inclusion criteria (clinical history readable and encoded for your records), registering INFORMATION MUST in Medscape Interaction Checker application (WebMD, LLC), where drug interactions also are classified according severity and nature of each obtained explained. The results were analyzed with SPSS.20 program for Windows, using descriptive analysis techniques and statistical significance, Pearson correlation coefficient. Results: 104 stories distributed according to their age group <60 years 20% (n = 21), between 60 to 70 years 34% (n = 35) and> 70 years 46% (n = 48) with an average age of 73 were studied ± 14.3 years. It was noted that all patients showed a variability in the number of drugs used corresponding to 26% (n = 27) 2 to 5 drugs used, 55% (n = 57) 6 to 9 drugs used and 19 % (n = 20) ≥ 10 drugs used. As for drug interactions it was observed that 85.6% (n = 89) had interactions of which 44% (n = 46) had between 1 to 5 interactions, 20% (n = 21) between 6 to 10 interactions, 15% (16) 11 to 15 interactions and 6% (n = 6)> 15 interactions. Likewise 66% (69) had pharmacodynamic interactions type and 34% (n = 35) pharmacokinetic interactions (2 absorption level interactions, 2 distribution, hepatic clearance 23, 4 and 4 renal elimination unknown). The Drug Interactions by consequence was distributed with 31% (n = 32) beneficial interactions, 52% (n = 54) harmful interactions and 17% (n = 18) banal interactions; and by severity 1% (n = 1) interactions were lower, 31% (n = 32) interactions moderate, 62% (n = 65) significant interactions and 6% (n = 6) severe interactions. and the number of drugs used (r = 0.9818; P.VALUE 0.0000) with total drug interactions, by correlating variables close and significant correlation between age (P-value = 0.9972 0.0000) was evident. Conclusions: The prevalence of drug interactions was high (85.6%), predominantly in the age group > 70 years with more than 6 drug interactions in a single patient, predominating pharmacodynamic interaction type , followed by the predominant alteration farmacocinteica Hepatica elimination level and more than 50% were negative and 62% were significant interactions ; this increases with the progressive increase in the number of drugs used, where it was observed that more than 55% consumed more than 6 drugs. Hence the importance of knowledge of the fundamental bases for the prevention of drug interactions become more relevant in the Older Adult population is the group most susceptible to poliimedicacion.

Palabras clave : Drug Interactions; Pharmacokinetics; Pharmacodynamics.

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