Abstract

REYES, María Gabriela et al. Growth Hormone, IGF-1, urine Calcium/creatinine ratio and Bone mineral density in acromegalic patients. AVFT [online]. 2017, vol.36, n.1, pp.1-9. ISSN 0798-0264.

Introduction: Acromegaly is produced by growth hormone (GH) hypersecretion after closure of conjunctival cartilage. It is considered as the cause of secondary osteoporosis. It produces different effects on bone, although bone mineral density (BMD) has not been unequivocally reported to decrease in these patients. Objective: to determine the relationship between serum levels of GH, IGF-1, calcium / creatinine ratio in urine and BMD in acromegalic patients. A descriptive and correlative research with a non-experimental and cross-sectional design was performed, including 20 acromegalic patients attended at the internal medicine and endocrinology clinic of the Central Hospital of Maracaibo Dr. Urquinaona. GH, IGF-1, calcium / creatinine ratio in urine, and bone mineral density were measured by dual X-ray absorptiometry (DXA). Results: It was shown that growth hormone levels in the first postprandial hour were directly proportional to fasting IGF-1 and inversely proportional to the values of the calcium / creatinine ratio, T score of the spine and T score of the femur, Evaluating the IGF-1 at fasting was observed to be inversely proportional to age, and to the femur T score. Regarding the T-score column is inversely proportional to age, age of diagnosis and GH, with respect to femur T score is inversely proportional to age, age of diagnosis, GH and fasting IGF-1. Conclusion: A behavior in which the GH is inversely proportional to the BMD values estimated by the T score of the spine and femur is similar to that evidenced when evaluating the IGF-1 is inversely related to the femur T score.

Keywords : acromegaly; osteoporosis; growth hormone; IGF-1.

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