Resumo

GARRIDO, L et al. Bronquiolitis Respiratoria como causa de Fibrosis Pulmonar (Br-Fp): Estudio Histopatológico y Ultraestructural de tres casos. RFM [online]. 2003, vol.26, n.2, pp.112-115. ISSN 0798-0469.

ABSTRACT: Respiratory Bronchiolitis is a lesion, that occurs, mainly in the lungs of cigarette smokers. Recently it has been shown that Respiratory Bronchiolitis, may cause pulmonary fibrosis and it is called to as Respiratory Bronchiolitis - Associated Interstitial Lung Diseases (RB-ILD). Histological, it shows peribronchiolar fibrosis and numerous macrophages, within the bronchiolar, and alveolar spaces with a fine granular pigment PAS positive and Prussian blue weakly positive, centriacinar emphysema, and hyperplasic alveolar pneumocytes. Ultra structurally, complex phagolaysosomes are present within the cytoplasm of intraluminal macrophages. The phagolaysosomes contain amorphous electron-dense debris as well as needle - shaped electron lucent particles referred to as "Smokers inclusions".     We study three open lung biopsy corresponding to three patients with clinical diagnostic of interstitial lung disease. Through morphological studies correlated with the clinical and x rays, we concluded that the diagnosis result was RB-ILD. We emphasize the importance of the morphological criteria and differential diagnostic of this pathology because, it responds to the treatment with steroids and with smoking cessation for which is considered the best prognosis than other interstitial lung diseases.

Palavras-chave : Bronchiolitis; Lung; Fibrosis.