Abstract

SOSA, A; SALAZAR-RODRIGUEZ, M  and  VELASCO, M. A comparison on Alkalinization Induced Effect on Lidocaine Anesthetic Activity. RFM [online]. 2004, vol.27, n.1, pp.79-82. ISSN 0798-0469.

ABSTRACT. Since some Anesthesiologists have reported side effects with the use of lidocaine in our country, we have made a pharmacological evaluation to define the anesthetic activity of lidocaine. The pharmacological evaluation was made in guinea pigs, by the method of Bülbring and Wajda⁽⁷⁾. For the statistical analysis of the different treatments, Analysis of Variance was used, as well as, the Theorem of Fieller for the potency of lidocaine. The AC₅₀ of commercial 2% lidocaine alkalinizated with 10% sodium hydroxyde was higher than that alkalinizated with 5% sodium bicarbonate and the standard USP (p £ 0,05). We have also evaluated the potency for commercial 2% lidocaine alkalinizated with 10% sodium hydroxyde below 60%. pH of the studied solutions and the adjusted-pH agent were determined, and we concluded that adjusted-pH agent was a determining factor in the anesthetic potency of lidocaine.

Keywords : Local anesthetic activity; Anesthetic potency; Adjusted-pH agent; Alkalinization of lidocaine.