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Revista de la Facultad de Medicina

versión impresa ISSN 0798-0469

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SOSA, A; SALAZAR-RODRIGUEZ, M  y  VELASCO, M. A comparison on Alkalinization Induced Effect on Lidocaine Anesthetic Activity. RFM [online]. 2004, vol.27, n.1, pp.79-82. ISSN 0798-0469.

ABSTRACT. Since some Anesthesiologists have reported side effects with the use of lidocaine in our country, we have made a pharmacological evaluation to define the anesthetic activity of lidocaine. The pharmacological evaluation was made in guinea pigs, by the method of Bülbring and Wajda(7). For the statistical analysis of the different treatments, Analysis of Variance was used, as well as, the Theorem of Fieller for the potency of lidocaine. The AC50 of commercial 2% lidocaine alkalinizated with 10% sodium hydroxyde was higher than that alkalinizated with 5% sodium bicarbonate and the standard USP (p £ 0,05). We have also evaluated the potency for commercial 2% lidocaine alkalinizated with 10% sodium hydroxyde below 60%. pH of the studied solutions and the adjusted-pH agent were determined, and we concluded that adjusted-pH agent was a determining factor in the anesthetic potency of lidocaine.

Palabras clave : Local anesthetic activity; Anesthetic potency; Adjusted-pH agent; Alkalinization of lidocaine.

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