Resumo

FUENMAYOR, Pedro José  e  GOMEZ, Jeiv Vicente. Comparación de la combinación hidroclorotiazida/bisoprolol con enalapril/amlodipina en el manejo de la hipertensión arterial no controlada. RFM [online]. 2008, vol.31, n.1, pp.45-51. ISSN 0798-0469.

The High Blood Pressure affects around 50 millions people in the EE.UU of America and a thousand million people all around the world, affecting 15 % to 30 % of the world’s population, and is one of the most important predictive factors of cardiovascular disease; therefore its control is essential. This study compared the antihypertensive action of the combination Hydrochlorothiazide/Bisoprolol with the combination Enalapril/Amlodipine in patients with uncontrolled High Blood Pressure diagnosis. Methods: We performed a randomized, controlled, clinical essay, in patients with High Blood Pressure between 30 and 65 years old, with High Blood Pressure previous diagnosis under treatment or not. They were distributed into two groups of 10 patients each one; one group received Hydrochlorothiazide/Bisoprolol, and the other one, received Enalapril/Amlodipine under a standardized regimen of titration according to BP goals during 4 weeks. Results: Both combinations reduced significantly BP values at 4 weeks of treatment (P= <0.0001). However, the antihypertensive effect of the combination Hydrochlorothiazide/Bisoprolol was superior in the reduction of diastolic values of BP (P= 0,025), and the reach of the 120/70 mmHg goal (90 % vs. 50 %). Conclusions: the use of the combination Hydrochlorothiazide/Bisoprolol is related to a higher number of benefits than the use of the combination Enalapril/Amlodipine in the management of patients with uncontrolled High Blood Pressure diagnosis.

Palavras-chave : Hypertension; Hydrochlorothiazide; Bisoprolol; Enalapril; Amlodipine; Clinical Essay.