Resumen

LAROCCA G, Nancy Elizabeth et al. Polimorfismos de receptores semejantes a Toll 2 y 4 en pacientes con asma bronquial y enfermedad pulmonar obstructiva crónica (EPOC). RFM [online]. 2008, vol.31, n.2, pp.116-122. ISSN 0798-0469.

Toll like receptors are important in the inflammatory immune response. Several mutations of these receptors have been related to the development and chronicity of different inflammatory diseases as bronchial asthma and obstructive pulmonary disease. A case control study was performed, 100 patients with bronchial asthma, 100 obstructive pulmonary disease and 100 controls. Restriction based polymorphism PCR analysis was performed for TLR2 (Arg677Trp and Arg753Gln) and TLR4 (Asp299Gly and Thr399Ile) genes and its association with asthma and obstructive pulmonary disease was assessed. The frequency of TLR4 polymorphism was 9 % in each group studied (asthma, obstructive pulmonary disease and controls). No association was found among TLR4 polymorphism and stage of disease for asthma or obstructive pulmonary disease. TLR4 polymorphism are not associated with the presence or severity of asthma or obstructive pulmonary disease in the Venezuelan population.

Palabras clave : Polymorphisms; TLR2; TLR4; Bronchial asthma; Obstructive pulmonary disease.