Resumen

RINCON A, Adriana C et al. Influence of gamma radiation as a sterilization method on polymer poli VPAVG (Valine- Proline- Alanine-Valine-Glicine). INHRR [online]. 2009, vol.40, n.1, pp.26-35. ISSN 0798-0477.

The poli polymer (VPAVG) belongs to the family of bioelastic materials derived from elastin, and it has showed the best qualities for the creation of systems of controlled cession, as well as an acceptable biocompatibility in certain tissues. If any preparation made from this biomaterial has to be administered in any way that implies the rupture of biological barriers, the preparation must be sterile. By this means, it is essential to know the behaviour of this polymer and its formulations, facing the sterilization process being used. The objective of this research was learn the influence of gamma radiation as a sterilization method over the physical characteristics of poli (VPAVG) and the particles formed by it. As the polymer, we did not observe any differences in physical appearance before and after sterilization. Particles formed by the polymer (VPAVG) and sterilized after, experimented changes in their morphology. As the size of the particles, we observed that those obtained with the sterilized polymer showed a tendency to form smaller aggregates than those found with the non-sterilized polymer. We concluded that the essayed biomaterial and its formulations were susceptible to gamma radiations as final sterilization method, proposing to use another treatment to guarantee the final sterile condition.

Palabras clave : Sterilization Method; Polymer Poli (VPAVG) (Valine-Proline-Alanine-Valine-Glicine); Gamma Radiation; Valine; Pro line; Alanine; Glicine; Bioelastic Materials.