Resumen

TOVAR H, Cerraf E et al. Clinical and epidemiological and molecular study of human metapneumovirus in patients with acute respiratory infections (ARI) in Venezuela. INHRR [online]. 2014, vol.45, n.1, pp.84-101. ISSN 0798-0477.

Human metapneumovirus (hMPV) has been associated with acute respiratory infections (ARI) in patients of all ages. Epidemiological studies indicate hMPV prevalence around the world, but in Venezuela little is known about its behavior in the population. This study aims to describe the epidemiological behavior of hMPV infection in Venezuelan patients. Were evaluated by RT-PCR multiplex 1812 nasal swabs (HN) from patients diagnosed with ARF and severe ARI (SARI) Influenza virus with negative results, referring to INHRR between 2010 and 2013. Of the non Respiratory Influenza Virus ( VRNI), the fourth hMPV virus proved more detected at a frequency of 9.1%. The 42.02% of hMPV positive cases were children ≤ 5 years with 29 cases (29/69). HMPV positive patients were enrolled IRA with high fever, cough, nasal congestion, dyspnea/ printing / rhinorrhea, malaise and stridor; and SARI inpatient (58%), pneumonia (36.2%), acute bronchitis (10.1%), bronchopneumonia (2.8%), nasopharyngitis and croup at 1.4%. Phylogenetic analysis of the hMPV showed the apparent relationship of the A2 and B2 genotypes with SARI. This study can prove the importance of the detection of other respiratory viral agents and their possible relationship with the development of IRA / SARI and strengthens epidemiological surveillance of respiratory diseases in Venezuela.

Palabras clave : Human metapneumovirus; Severe Acute Respiratory Infections; Respiratory Viruses; Epidemiological Surveillance.

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