Resumo

BORGES GARNICA, Alfredo José et al. Asociación de catepsina D con factores pronósticos en melanoma maligno . Rev. venez. oncol. [online]. 2005, vol.17, n.3, pp.135-140. ISSN 0798-0582.

SUMMARY OBJECTIVES: To determine the association of cathepsin D, like immunehistochemical prognosis factor, in order to improve our therapeutic arsenal. METHODS: We reviewed the clinical histories of 23 patients with diagnosis of malignant melanoma treated in the Instituto de Oncología Dr. Miguel Perez Carreño, in the lapse of January of 1998 and December of 2001, to which, the determination of cathepsin D was made in the paraffin blocks of the made biopsies RESULTS: The inmunehistochemical mark procedure with cathepsin D was made in 23 patients according to the revealed technique of aminoetilcarbazol. The results were related to the presence of factors prognoses. The patients with positive inmunemarked 41.17 % are Clark IV, 41,17 % Breslow > 3 mm, 70,58 % presented ulceration, 52,94 % were stage III. CONCLUSIONS: A parallelism between the histological factors and the inmunemarked with cathepsin D was demonstrated, but the natural evolution of those patients in initial stages is due to determine to be able to determine its value like factor prognosis.

Palavras-chave : Melanoma; cathepsin D; inmunehistochemestry; prognostic factors.