Abstract

SUAREZ, Carmen María; MIJARES BRINEZ, Alirio; CASTILLO MARRERO, Livia  and  BRICENO, Josefa María. Tipificación del vph en cáncer de cuello uterino en la población venezolana. Rev. venez. oncol. [online]. 2006, vol.18, n.4, pp.221-225. ISSN 0798-0582.

OBJECTIVES: Identify and typify human papilloma virus in patients with cancer of the uterine cervix in the venezuelan population. METHODS: We included 53 patients with diagnosis of cancer of the uterine cervix between April 2004 and November 2005. Polymerase chain reaction was used to typify human papilloma virus types 6, 11, 16, 18, 31, 33 and 35. Other variables such as age, tumor stage and histology were analized. RESULTS: Mean age was 44.79 years. The majority of patients had diagnosis of locally advanced uterine cervix cancer (43.18 % St IIb, 40.90 % St IIIb and 2.27 % St IVa). The predominant histology was epidermoid carcinoma in 83.36 % of cases, followed by adenocarcinoma in 11.36 % and adenosquamous carcinoma in 2.27 %. When human papilloma virus identification and typification was performed using PCR, the presence of DNA sequences associated with human papilloma virus were not found in 28 patients (52.83 %). DNA sequences associaed with human papilloma virus type 16 were identified in 13 patients (24.52 %), with human papilloma virus type 18 in 4 patients (7.54 %), human papilloma virus 31 in 3 (5.66 %), human papilloma virus 6 in 2 (3.77 %) and human papilloma virus 11, human papilloma virus 33 and human papilloma virus 35 in one case respectively (1.88 %). CONCLUSIONS: The results obtained with human papilloma virus identification and typification in our patient population is different from those reported in other countries. Epidemiological studies that include other high risk virus types must be performed.

Keywords : Cancer; uterine cervix; Human papilloma virus; Polymerase Chain Reaction.