Abstract

ZENZOLA, VÍCTOR  and  INSTITUTO ONCOLOGICO LUIS RAZETTI. SERVICIO DE GINECOLOGÍA ONCOLÓGICA et al. Comparación entre quimiorradioterapia definitiva y quimiorradioterapia y cirugía  en cáncer de cuello uterino estadios Ib2 y IIa. Rev. venez. oncol. [online]. 2007, vol.19, n.1, pp.42-50. ISSN 0798-0582.

OBJECTIVE: To compare treatment of patients underwent definitive chemoradiation with patients that offer surgery after treatment with chemoradiation for cervical cancer stage IB2-IIA. METHODS: From January 2001 to April 2006, 86 patients with cervix cancer stage IB2IIA were selected. Identified 3 groups of treatment: 1 Chemoradiation alone (external chemoradiation plus brachytherapy): 44 patients. 2 External chemoradiation followed by extended hysterectomy class II (27 patients). 3 External chemoradiation plus brachytherapy followed by extended hysterectomy class I (15 patients). The endpoints were based compare the clinical and pathologic response, overall survival, disease free survival and complications. RESULTS: The median duration of follow-up has been 24 months (range 4 to 64). The groups underwent surgery complete pathologic response was achieved in 60 % (posthisterectomy class I) and 33 % (posthisterectomy class II). At 64 months, the disease-free survival rate was 61.36 %, 59.2 % and 60 % respectively. No significant difference was found in overall survival or disease free survival group when we aplicated the same 3 different statistics method to the 3 groups. No serious complications were registered. DISCUSION: the applicator surgery post complete integral chemoradiation treatment did not improve the pelvic control rates, and the overall survival rates, nor disease-free survival rates for patients with cervix carcinoma stage IB2-IIA. In patients when brachytherapy is not available to perform a extended ampliated hysterectomy class II after external chemoradiation is an acceptable alternative, to guarantied an adeccuated locoregional control of the disease.

Keywords : Cervix cancer chemotherapy; radiation-therapy; surgery.