Resumo

GUERRA DE BERRIZBEITIA, DANIELA  e  CENTRO DE INVESTIGACION Y DESARROLLO DE RADIOFARMACOS CEIDRAF. FACULTAD DE FARMACIA. UCV. HOSPITAL UNIVERSITARIO DE CARACAS. CLINICA ATTIAS. CARACAS, VENEZUELA et al. Eficacia del radiofármaco 153sm-edtmp en dolor y metástasis ósea  . Rev. venez. oncol. [online]. 2007, vol.19, n.2, pp.105-117. ISSN 0798-0582.

OBJECTIVE: In the Venezuelan Central University, Radiopharmaceuticals Research and Development Center laboratory has be developing a method of prepared and to obtain, in a close system and in ambient temperature a 153Sm-EDTMP radiopharmaceutical for use in vein administration by metabolic systemic radiotherapy to relief the chronic pain related with patients with bone metastases disease. METHODS: With the finally to evaluate effectiveness, of the clinical protocol was designed, it was approved by the Caracas University Hospital Bioethical Committee. According to this protocol 15 patients were selected with bone metastases disease diagnoses, all of them manifested bone pain. All the patients received a first dose (1 mCi/kg) of the radiopharmaceutical, 3 months later only 4 of the patients received a second treatment with an equal dose (1 mCi/kg) each one. It was registered weekly reports in three different scales the pain relief, the quality life and the analgesics use. RESULTS: The results show that with each dose administrated of the radiopharmaceutical 153SmEDTMP a significant pain relief is achieved, the use of analgesics decrease and therefore the patient’s life quality improves. CONCLUSION: 153 EDTMP prepared in our university center constitute and good valid and viable alternative, for his facile access and use for the palliative treatment in the metastases bone diseases. The application of this clinical protocol, for evaluation of 153 EDTMP radiopharmaceutical, in the therapy of the bone metastases diseases, let us to confirm the role and his efficacy in these cases.

Palavras-chave : Dolor óseo; metástasis óseas; radiofármaco; radioterapia metabólica; Bone pain; bone metastases; radiopharmaceutical; metabolic radiotherapy.