Abstract

VALERO, RORAYMA  and  HOSPITAL MILITAR DR. “CARLOS ARVELO”. CARACAS, VENEZUELA et al. Linfoma de hodgkin extranodal: Reporte de un caso y revisión de la literatura. Rev. venez. oncol. [online]. 2007, vol.19, n.2, pp.147-151. ISSN 0798-0582.

OBJECTIVES: To study a patient with extranodal Hodgkin lymphomas in the extranodal subtypes there was hepato-esplenic. It’s frequent in 3ª and 4ª decade of life predominates, in males, and they have an expectancy of life between 3-5 years. RESULTS: 35 years old male patient, with the diagnosis of bacterial endocarditis of native aortic valve. Referred to our hospital because persist fever after receiving treatment for 30 more days, with multiple antibiotics. Before the discharge the serum enzymes began to raise 2-3 times the normal value, TB: 9 mg %, AP: 1200 UI/L, he referred to have fever during approximately 8 months, lost of weight of 4 - 5 kg. Abdominal echo: Hepatic lesion LOE in splenic segment VII and LOE. Ca19.9 alpha fetoprotein, carcinoembrionic antigen were negative, upper and lower endoscopy, thorax and neck TAC abdominal reported normal MRI: Hepatomegaly, hepatic lesion in segment VII splenomegaly with a 3.5 cm mass. Lumbar column MRI: Multifocal bony marrow injuries of vertebral bodies L1 to L5. A percutaneous hepatic biopsy was made: Hepatic infiltration by Hodgkin lymphoma. The diagnosis was corroborated by Immunohistochemestry Patient received chemotherapy with normalization of liver tests and disappear the lesions. CONCLUSIONS: Hepato-splenic Hodgkin lymphoma is infrequent and indicates aggressive clinical courses, often it is insufficient the material of diagnosis confirmation. Has a varied clinic presentation. It has a bad development and in multiple occasions diagnosed post mortem since its low incidence does not wake up suspicion clinical.

Keywords : Extranodal Hodgkin lymphoma; hepato-splenic lymphoma.