Abstract

LIUZZI, JUAN  and  SERVICIO DE CABEZA Y CUELLO - HOSPITAL ONCOLOGICO” PADRE MACHADO”, LABORATORIO DE GENETICA MOLECULAR DEL INSTITUTO DE HEMATO-ONCOLOGIA DE LA UNIVERSIDAD CENTRAL DE VENEZUELA et al. Tipificación del virus del papiloma humano  en carcinoma de células escamosas de cabeza y cuello. Rev. venez. oncol. [online]. 2007, vol.19, n.3, pp.210-218. ISSN 0798-0582.

OBJECTIVES: Head and neck squamous cell carcinoma is a disease attributed to tobacco and alcohol abuse; however, human papillomavirus also represents a potential risk factor for this malignancy. METHODS: We examined tumor specimens from 29 patients with histological confirmed, newly diagnosed at the head and neck department of the Oncology Hospital “Padre Machado”. Fresh tumor specimens were frozen and stored at -80º C until processing. We determined the presence or absence of high-risk or low-risk DNA in all tumor tissues by using polymerase chain reaction demographic data, including age at diagnosis; sex, alcohol, tobacco exposures, tumor site, stage, and grade were documented. The t Student-test was used to examine the association of virus with these factors. RESULTS: 34.48 % were positive to AND of virus. The low risk virus was the implicated. Current smokers in virus positive were most frequent than in negative if it was recent and the tumors mainly located in oral cavity. Gender, age, alcohol consumption, grade, size, lymph nodes status, clinical stages were not significant stadistic associated with presence of virus. CONCLUSIONS: The majority of studies of head and neck squamous cell carcinoma have focused on high grades virus how 16 and 18 in the etiology of this tumors Other types-such as 6 and 11 -have not been identified in many head and neck malignancies. Our findings suggest that virus 6 and 11 may play a role in the etiology of head and neck squamous carcinoma.

Keywords : Cancer; head and neck; human papillomavirus.