Abstract

HERNANDEZ, Dimas. Linfoma no hodgkin difuso Virus de inmunodeficiencia humana: Uso del factor estimulante de colonia de granulocitos. Rev. venez. oncol. [online]. 2007, vol.19, n.4, pp.297-301. ISSN 0798-0582.

OBJECTIVE: The routine use of stimulant colonies factor of macrophages and granulocytes for 10 days during complete treatment doses of ciclofosfamide doxorubicin vincristine and prednisone in patients with lymphomas diffuse no Hodgkin immune deficiency virus acquired associated is very expensive to be financiered in the third world countries. The main objective of this paper is to define the more rational use of this stimulant factor. METHODS: We treated 22 patients with lymphomas diffuse no Hodgkin associated with virus immune deficiency acquired with standard dose of the chemotherapy regimen before mention for us, and the used of stimulant colonies factor after an episode of febrile neutropenia until the neutrophilos achieved and absolute count of 1 000/mm3. RESULTS: A clinical response was obtained: complete response (36 %), partial response (32 %), stable disease (14 %) and progression (18 %). There was no death related with the toxicity. Grade 3 or 4 neutropenia was observed in 16 % of the cycles but only 8% of the patients were complicated with febrile neutropenia. Seventeen patients were died (median survival 15 months; range, 2 - 70 months). There are five patients still alive (median survival 24+ months; range, 17 - 36+ months). CONCLUSIONS: Our experience showed that we can treat lymphoma no Hodgkin diffuse associated with immune deficiency acquired virus with complete dose of chemotherapy, achieve good responses and have excellent and acceptable toxicity profile, with the use of stimulant colonies factors as needed and not for routine.

Keywords : Non Hodgkin lymphoma; chemotherapy; stimulant colonies factor; virus; immunodeficiency.