Abstract

GODOY BRICENO, Alí Josué; BETANCOURT, Luís; PARADA, David  and  MORALES, Sergio Osorio. Factores predictivos de metástasis Ganglionares axilares, en Cáncer de mama menor de 2 centímetros. Rev. venez. oncol. [online]. 2007, vol.19, n.4, pp.302-312. ISSN 0798-0582.

OBJECTIVES: To identify and study that existing pathologically factors and clinical predict nodal metastases axillaries in mammary tumors with diameter size more and minor of 20 mm, so demonstrated in the axillaries dissection is an unnecessary procedure in most of these patients, and can omit with surely in patients with favorable predictive factors. METHODS: We realize a retrospective study, review the macroscopic and microscopic reports, and the inmunohistochemestry in the cellular blocks of patients with breast carcinoma with size until 20 mm treated in the Oncology Institute "Dr. Luis Razetti", between January and December of 2000 - 2003, determining factors that influence in the appearance of lymph nodes axillaries positives, making unvaried and multivariate analysis. RESULTS: These work consisted in the studied of 121 patients with mean age 57 years, 50 (41, 32 %) presented axillaries disease nodes metastases; the factors that were related to positive lymph nodes in the unavailable analysis were: histological and nuclear grade, linfovascular invasion, mitotic index high, aneuploid tumors (P< 0,05). In the multivariate analysis, the linfovascular invasion, mitotic indices elevated and aneuploid tumors were independent factors to predict the axillaries metastases (P< 0,001). CONCLUSIONS: The linfovascular invasion is main predictive factor of axillaries lymph node positive in the breast cancer stratified how T1, these situation and combined with other factors like mitotic indices and tumor ploidy, can indicate to us that patient them the axillaries dissection can be omitted surely to diminish the complications.

Keywords : Cancer; breast; lymph nodes; metastases; axillaries; prognosis.