Resumen

PONCE, José Gregorio et al. Evaluación de oncógenes y moléculas de proliferación celular en carcinoma escamoso de cavidad oral. Rev. venez. oncol. [online]. 2008, vol.20, n.2, pp.63-70. ISSN 0798-0582.

The oral cavity cancer account for 30 % of all of head and neck cancers, among which 95 % are squamous cell type carcinoma. There are described many risk factors involved, and in the last few years there is been a wide a series development of cell proliferation molecules and oncogenes, in which can be over expressed in the patients with squamous cell cancer of the oral cavity. The objective of this investigation is to evaluate the proliferation cells marker Ki-67 and PCNA and the p53, p21 oncogenes and the c-erB2 in patients with squamous cell carcinoma, localized in oral cavity and his correlation with clinical and pathological factors in the evaluated group. METHODS: To the biopsies of 52 patients with squamous cell carcinoma of oral cavity seen in the Oncology Hospital “Padre Machado” between 1995 and 1999 there were evaluated with inmunohistochemestry techniques to determine Ki- 67 and PCNA cell-proliferation markers and p53, p21, c-erbB2 oncogenes. RESULTS: The proportion of positive results found were: In the inmunohistochemestry: 90.4 % PCNA, 63.5 % p21, 53.8 % Ki-67, 48.1 % p53 and 3.8 % in c-erbB2. In our study, the vascular permeability and the differentiation degree were significant in this study with the correlation of the presence of the p53, p21, c-erbB2, PCNA and Ki-67. CONCLUSIONS: The PCNA and p21 were the most common found biomarkers. The vascular permeability and the histological grade show a significant statistic relation with all study biomarkers.

Palabras clave : Protein; p53; neoplasm; carcinoma; squamous cell.