Abstract

BERMUDEZ V, Cecilia  and  RARADA D, David. Estudio Inmunohistoquímico del carcinoma de glándula mamaria en el Hospital Vargas de Caracas. Rev. venez. oncol. [online]. 2008, vol.20, n.2, pp.78-90. ISSN 0798-0582.

To study and assess the association between different morfhological and pathologic features and immunohistochemistry as a prognostic factor. METHODS: A retrospective-descriptive study of 651 cases of breast cancer by immunohistochemistry markers was analyzed in the Vargas Hospital of Caracas since May 2001 until July 2004. We evaluate the pathologic features of the different tumor subtypes, and relation this with the expression of immunohistochemistry markers: The estrogen receptor, progesterone receptor, c-erbB-2 and Ki-67, made by the biotin-streptavidin technique. RESULTS: The median patient age was 51.72 years. The most frequent type of tumor was the invasive duct carcinoma (88.7 %), follow by the invasive lobular carcinoma (4.6 %). The 5.5 % of the duct carcinomas were well differentiated tumors, 42.3 % moderate differentiated, and 52.2 % poorly differentiated; in which 77 % had estrogen receptor and progesterone receptor ≤ 10 %, well differentiated tumors show a variable positivity. The poorly differentiated tumors show positive c-erbB-2 in 51.36 %, in the well-differentiated group 81.84 % were negative; the c-erbB-2 on intraductal carcinoma was positive in 42.86 %, generally associated with the comedocarcinoma; the 94.7 % of the poorly differentiated tumors were Ki-67 positives. CONCLUSIONS: Classic invasive duct carcinoma is the most frequent malignant tumor, with a median age of 51.5 years, and the poorly differentiated tumors generally show an aggressive biologic conduct, associated to patients with estrogen receptors and progesterone receptors negative tumors and a high expression of the c-erbB-2 y Ki-67.

Keywords : Carcinoma; infiltrating; ductal; estrogen receptor; progesterone receptor; c-erbB-2; Ki-67.