Abstract

RODRIGUEZ, Yuraima et al. Histiocitosis de Células de Langerhans con afectación Gástrica: Reporte de caso, Revisión de la Literatura. Rev. venez. oncol. [online]. 2008, vol.20, n.2, pp.91-97. ISSN 0798-0582.

Langerhans cell histiocytosis is a spectrum of infrequent and poorly understood diseases. Etiology remains essentially unknown despite of number studies. Clinical manifestation depends of the extension of disease and organs compromised. The gastrointestinal involvement is extremely rare and changes the staging of the disease, its presence is indicative of multisystemic disease and aggressive treatment should be considered. The case reported is of a seven years old child with chronic non progressive encephalopathy and epigastric mass , gastrointestinal symptoms for one and half months, diagnostics proposed where gastric tumor, vs. lymphoma, however the anatomophatologic and immunohistochemical evidence concluded in gastric histiocytosis. Treatment with quimioteraphy was according to Protocol LCH - III second for high risk disease with prednisone and vinblastin during six weeks, toward the end of the first cycle patient showed good response Literature review reports few cases with small intestine and colon involvement, no reports with gastric involvement where found.

Keywords : Histiocytosis; Langerhans cells; gastric; mass.