Resumo

VEITIA, Dayahindara et al. Detección de VPH y expresión de p53 en carcinoma de cabeza y cuello. Rev. venez. oncol. [online]. 2009, vol.21, n.3, pp.123-131. ISSN 0798-0582.

The head and neck cancer has been frequently associated with the alcohol and tobacco abuse consume, although there are a low percents of cases that have not an alcohol and tobacco history know. This has made to consider another risks exposure factors how for example, the human papilloma virus. At present the oncologist evaluate different oncogenic markers inside them like the p53, this permit to them realize a better prediction and the prognostic. The objective of this study was evaluating the human papilloma virus infection in the patients with diagnostic of head and neck carcinoma using the polymerase reaction chain, such as the detection of the p53 by the immunohistochemistry procedure. Of the 30 evaluated samples 12 (40 %) of them result positive to the human papilloma viral detection, of these the 58 % correspond to the human papilloma virus type 11 (low oncogenic risk), been the oral cavity the anatomic localization most affected by the viral genome presence. The p53 has been finding in the 50 %, the orofaringe was the anatomic localization who has most positive to the marker.

Palavras-chave : Cancer; head; neck; PCR; HPV; immunohistochemestry; p53.