Resumen

RAMIREZ CASADIEGO, Ana Karina  y  BIANCHI, Gino Italo. Carcinoma de la mama triple negativo aspectos morfológicos y expresión de CK 5/6. Rev. venez. oncol. [online]. 2011, vol.23, n.1, pp.2-13. ISSN 0798-0582.

Breast cancer is heterogeneous disease classification parameters prognostic factors are not always predictors its clinical course. Molecular genetics are categorizing in different ways, as the well-known morphologic classification. Studies endorse specific group within this classifying system: Basal-like carcinomas, has worst prognosis; tends to be triple-negative: ER (-), RP (-), Erb-B2(-); expresses basal cytokeratins, such as cytokeratin 5/6 (CK5/6). Considered determining morphological aspects, frequency in which they express CK5/6 through immunohistochemistry, and contrasting them to existing clinical parameters. 91 carcinomas were selected between the years 2003 - 2008 and checked for CK5/6. Or the aforementioned cases, 34 (37.4 %) resulted TN-CK5/6(+) and 57 (62.6 %) resulted TN-CK5/6(-). Morphological aspects described for and carcinomas were observed in both groups, though they were more frequent in breast carcinomas TN-CK5/6(+). For this reason, detecting these tumors using immunohistochemistry is a practical, worthwhile, and convenient way to identify this group with the worst prognosis on our daily routines.

Palabras clave : Cancer; triple negative; basal; morphological; immunohistochemistry; CK5/6.