Resumen

GARCILAZO A, Dimas J; SANOJA C, Eduardo I; SANOJA C, Lucila  y  MOSCHELLA S, Filomena. Neoplasias sólidas de células redondas en edad pediátrica correlación entre diagnóstico morfológico e inmunohistoquímica. Rev. venez. oncol. [online]. 2011, vol.23, n.3, pp.175-183. ISSN 0798-0582.

OBJECTIVES: To precise the state and the importance of the study of immunohistochemistry and its correlation with the routine pathological diagnosis to use in diagnosis of malignant solid tumors of round cells in pediatric patients. METHODS: We was performed a transversal, descriptive and retrospective non-experimental study. We studied 147 patients diagnosed with round cell tumor, 96 of them were met in inclusion criteria. RESULTS: The highest frequency of the cases was Non-Hodgkin lymphoma (20.8 %), followed by the Hodgkin lymphoma (15.6 %) and the Wilms tumor (17.7 %). The age group most affected was the school (37.5.%). The male gender was the predominant (60.4 %). The most frequent clinical manifestations were a palpable mass (76.04 %), the fever (44.79 %), the anemia (41.67 %), the pain (41.30 %) and the weight loss (33.33 %). Evidenced the highest correlation in the diagnosis of Wilms tumor (100 %), followed by Non-Hodgkin lymphoma (80 %) and Hodgkin lymphoma (75 %); showed the lowest correlation between the Ewing sarcoma and neuroblastoma (41.7 %, both). The total correlation is “considerable” according to strength of agreement the Kappa coefficient (k: 0.601. P=0.000). CONCLUSION: It requires the integration of routine histopathological examination as diagnostic method of research and study of immunohistochemistry as an auxiliary diagnostic method to determine the histogenesis of neoplasm and exclude the differential diagnoses, make an appropriate therapeutic design and the determine prognosis of this group of patients.

Palabras clave : Neoplasm; round; cells; hematoxylin; eosin; immunohistochemistry.