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Anales Venezolanos de Nutrición

versión impresa ISSN 0798-0752

Resumen

RUIZ FERNANDEZ, Nelina A  y  SOLANO, Liseti. La inmunosenescencia y el papel de la nutrición. An Venez Nutr [online]. 2001, vol.14, n.2, pp.86-98. ISSN 0798-0752.

Functional capacity of immune system decline gradually with age. T-lymphocytes cells are affected more profoundly than B-lymphocytes. This difference is mainly attributed to thymic involution that reaches maximum after 60 years of age. Aging is associated to changes in the equilibrium of lymphocyte subpopulations, like an increase of immature CD2+CD3-T cells, memory T-cells (CD45RO), helper TH2 T-cells and CD5+ B-cells; more than to a decrease in total count of lymphocytes. Nutrition have a very strong influence on immune system and its response in elderly people. Nutritional deficiencies exert accumulative effects on immune senescence. In elderly persons, nutritional supplementation can restore or prevent the decline of immune response. Interactions between immunity, aging and nutritional status are reviewed.

Palabras clave : Aging; immune system; nutrition; zinc; cellular immunity; humoral immunity.

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