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Anales Venezolanos de Nutrición

versión impresa ISSN 0798-0752

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MACIAS DE TOMEI, Coromoto. Metabolic syndrome in children and adolescents: What is new?. An Venez Nutr [online]. 2014, vol.27, n.1, pp.96-100. ISSN 0798-0752.

Metabolic Syndrome (MS) includes anthropometric, clinic and metabolic changes that predispose to the development of diabetes type 2 and cardiovascular diseases. MS results from the interaction of genetic and environmental factors mediated by epigenetic regulation; some loci have greater effect on metabolic phenotypes modified by diet and other environmental factors. Once MS components are characterized, several studies focus on the best predictors to identify cardiometabolic risk in adults: Waist circumference (WC) and insulin resistance (IR). Obesity during pregnancy and IR in fetal tissues is associated to high risk of MS in children and adolescents. In young adults there is a higher prevalence of high blood pressure and IR in children born preterm (weight < 1500 g) vs. children born at term, without significant differences in lipidic profile between both groups. Recent studies have proposed the association between low intake of ώ-3 and high intake of ώ-6 fatty acids in infants with latter appearance of MS characteristics: dyslipidemia, IR and hyperphagia. Non-diabetic obese adolescents with MS were found to have lower arithmetic skills, spelling and mental flexibility and inappropriate performance in cognitive evaluations when compared with their healthy peers. Decreased microstructural integrity of the white matter and smaller hippocampus volume that may cause cerebral complications at short time was found. Early physiological puberty and skeletal development have been described in obesity, but no information is available in obese patients with MS. In obese 9-16 years old, we found high percentage of advanced bone age in those with MS criteria.

Palabras clave : Metabolic syndrome; central obesity; insuline resistance; children; adolescents.

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