Abstract

VALERO, Yolmar; COLINA, Jhoana  and  HERRERA, Héctor. Intestinal microbiota and its role in diabetes. An Venez Nutr [online]. 2015, vol.28, n.2, pp.132-144. ISSN 0798-0752.

The incidence of obesity, disorders associated with metabolic syndrome and type 2 diabetes have increased in the last decade. These conditions can be influenced by genetic, environmental factors and pathways linking metabolism to the immune system. Thus, an abnormal energy metabolism and a low level chronic inflammation of the adipose tissue is observed. The incidence of these disorders can become genetic susceptibility and changes in the lifestyle of each individual. In addition to this, it has been suggested the influence of intestinal microbiota in the prevalence of such conditions. Recent data indicate that the population of microorganisms living in the intestine, can influence nutrient absorption and energy storage. All this contributes to a positive energy balance consisting in increased energy from the diet. It has been implicated in the mechanisms influence of inflammation and immune response associated with such pathology. In-depth knowledge of the role of intestinal microbiota in the onset of diabetes in the host is required. In this review recent results obtained in studies focusing on the contributions of gut microbiota to diabetes are collected.

Keywords : Intestinal microbiota; diabetes; obesity; inflammation; prebiotics and probiotics.

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