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versión impresa ISSN 0798-2259

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MARTINEZ, Eustacia Coromoto; REY-VALEIRON, Catalina; ROMERO, Hilda  y  YEGRES, Francisco. Inflamatory and Antibody Responses against Cladophialophora carrionii in Goats. Rev. Cient. (Maracaibo) [online]. 2006, vol.16, n.2, pp.113-117. ISSN 0798-2259.

Cladophialophora carrionii is a dimorphic fungus with melanin which causes a deep, localized and chronic mycosis in humans, named chromomycosis, acquired through inoculation with cactuses infected-spines. Falcon state is an endemic zone to this disease, where human populations make use of goat breeding as their main way of living. The objective of this work was to evaluate both humoral immune and inflammatory responses against C. carrionii in goats to improve knowledge about host-parasite interactions in a species usually considered as infection-resistant, in spite of permanent exposition to infected spines. Six kids were inoculated with 1 ×106 cells of C. carrionii, by subcutaneous route on the neck. Blood and sera samples for hematological and immunoenzimatic tests were taken and body temperature was also measured. The diameter of the inoculated skin was also evaluated 24 and 48 hours post-inoculation. Inflammatory response was considerable at 48 hours. There was no valuable response of antibodies. It is established that inflammatory response is important in resistance against C. carrionii, but antibody response seems not to be relevant for this animal specie.

Palabras clave : Goats; chromomycosis; Cladophialophora carrionii; antibodies.

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