Resumo

SANDOVAL, Osvaldo et al. Comparison of the Preventive Analgesic Effect Between Tramadol and Morphine Associated to Xylazine in Canine Ovaryhisterectomy. Rev. cient. (Maracaibo) [online]. 2010, vol.20, n.2, pp.138-143. ISSN 0798-2259.

The objective of the present study was to compare and evaluate the postoperative analgesic effects after the preventive administration of Tramadol and Morphine combined with Xylazine in canine ovarihysterectomy. Twenty four adult bitches without distinction of race and age were used. Animals were randomly assigned to three different groups receiving respectively: Control Group: 0.5 mg/kg Xilazine, Tramadol Group 0.5 mg/kg xilazine + 3 mg/kg Tramadol and Morphine Group: 0.5 mg/kg Xilazine + 0.4 mg/kg Morphine. Surgeries were carried out without complications under general anaesthesia under Isoflurane. Pain evaluations started 30 minutes after removing the endotracheal tube and carried out for 10 hours every thirty minutes for the first six hours and then every hour. Pain scores were determined using a numerical rating scale. Pain scores between different treatments were analyzed using Kruskall-Wallis non-parametric analysis of variance. A value of P<0.05 was considered to be statistically significant. Pain scores showed significant differences (P<0.05) between control and Tramadol groups at third, third and a half, fourth and seventh hour. Similarly at six, nine and ten hours of evaluation significant differences (P<0.05) between control and Morphine groups were found. Finally at four hour thirty minutes, the five hours thirty minutes and the eigth hour these significant differences (P<0.05) were between control and Morphine and Tramadol groups. It can be concluded that Tramadol and Morphine are effective and safe for the control of early post surgical pain in canine ovariohysterectomy.

Palavras-chave : Morphine; Tramadol; analgesia; canine.