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Revista de la Facultad de Ingeniería Universidad Central de Venezuela
Print version ISSN 0798-4065
Abstract
ROCHE, Rossany et al. Simulation of a cardiac cell: Part II: applications. Rev. Fac. Ing. UCV [online]. 2009, vol.24, n.1, pp.89-105. ISSN 0798-4065.
A simulator of the cardiac cell (E-C coupling process) is developed in this work, which solves the electro-chemical model of the cell proposed by Roche et al. (2004). It also contains other mathematical models as well, namely, those by Tang & Othmer (1994) and Fox et al. (2001), for comparison purposes. The simulator allows the modification of the model parameters in correspondence with the different cellular elements, to emulate cells of different species or cells under different conditions. The paper also contains an application of the simulator for testing the sensitivity of the E-C process to drugs and inhibitors, showing its intended use as a research tool in experiment design and cardiac pathology treatment.
Keywords : Cardiac simulation; Cardiac cell; E-C coupling; Calcium dynamics; Cellular simulation.