Resumo

HERNANDEZ, Anabel et al. Metronidazole and tinidazole effects on Trichomonas muris in hamsters. Zootecnia Trop. [online]. 2008, vol.26, n.1, pp.71-77. ISSN 0798-7269.

The main purpose of this research was to evaluate and compare metronidazole and tinidazole efficacy against Trichomonas muris in hamsters naturally infected and raised under conventional bioterio conditions. There were selected 40 male hamsters based on positiveness to T. muris infection diagnosed for demonstration of the trofozoites on the direct coprological observation. For this purpose metronidazole and tinidazole were administered daily, initially given in one intake during five days at concentrations of 2.5, 5, 6.25, and 7,5 mg/mL by oral way during five days. Thereafter, a second treatment was imposed with two intakes at 7.5 mg/mL. In the first five days of treatment 1, it was obtained a 20% of parasite elimination using tinidazole at a 6.25 mg/mL concentration. A similar response at was obtained by metranidazole at a concentration of 7.5 mg/mL. Additionally, tinidazole efficacy was 40% at a concentration of 7.5 mg/mL. Regarding treatment 2, it was found 100% of effectiveness for tinidazole at 7.5 mg/mL, whereas effectiveness for metronidazole was 50%, with an effective eradication specter lower than the seven days period. It is evidence of a low efficacy of the drugs against tricomicide activity. It is recommended to realize in vitro studies in order to evidence parasite resistance to synthetic drugs derived from nitroimidazole and to stimulate the study and development of new alternative drugs able to proportionate experimental models useful for research.

Palavras-chave : Metronidazole; tinidazole; hamster; Trichomonas muris; protozoa.

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